Dr. Oliveira´s research group
Overview: Our research is focused on peptidases that act inside mammalian cells. We have investigated the structure-activity relationship of these peptidases, specially their substrate specificity and factors that regulate the activities of these enzymes in the intracellular environment (e.g. oxidative-reductive events and protein-protein interactions).
Two main research projects are currently active:
Studies on the structure-activity of intracellular oligopeptidases (TOP, PREP and PREPL);
Development of cyclic-peptide inhibitors for viral proteases (NS2B/NS3 proteases from Dengue Virus and Zika virus).